The present study was aimed to develop a Chronotherapeutics based delayed total release tablet of Carvedilol with a lag time of 6 h. Full factorial 32 design (Minitab 16.0) used in this study provided valuable and efficient method to yield an optimized formulation. The independent variable used in this study includes concentration of SSG (% w/w) and percentage weight gain while drug release at 6 h was considered as response variable. A mathematical relationship, Y1= 73.77 + 1.56 X1 -7.5 X2 – 0.166 X1X1 + 3.83 X2X2 -2.1 X1X2 was obtained to explain the effect of all factors and their interactions on the dissolution of carvedilol at 6 h. From the in-vitro dissolution study it was observed that optimized batch displayed drug release of 88% in 6 h.
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